Brenner Lab Older News

• Paper published: Chandonia JM, Fox NK, Brenner SE. 2019. SCOPe: Classification of large macromolecular structures in the Structural Classification of Proteins—extended database. Nucleic Acids Research 47:475-481. PMID:30500919. doi:10.1093/nar/gky1134
• Paper published: Peters B, Brenner SE, Wang E, Slonim D, Kann MG. 2018. Putting benchmarks in their rightful place: the heart of computational biology. PLoS Comput Biol 14:e1006494. doi:10.1371/journal.pcbi.1006494
• Paper published: Ghosh R, Harrison SM, Rehm HL, Plon SE, Biesecker LG, on behalf of the ClinGen Sequence Variant Interpretation Working Group. 2018. Updated recommendation for the benign stand-alone ACMG/AMP criterion. Human Mutation 39:1525-1530. PMID:30311383. PMCID:6188666. doi:10.1002/humu.23642
• Paper published: Abou Tayoun AN, ClinGen SVI et al. 2018. Recommendations for interpreting the loss of function PVS1 ACMG/AMP variant criterion. Human Mutation 39:1517-1524. PMID:30192042. PMCID:6185798. doi:10.1002/humu.23626
• Paper published: Dyke SOM et al. Registered access: authorizing data access. European Journal of Human Genetics. doi:10.1038/s41431-018-0219-y
• Paper published: Arkin AP et al. KBase: The United States Department of Energy Systems Biology Knowledgebase. Nature Biotechnology 36:566-569. PMID:29979655. PMCID: PMC6870991. doi:10.1038/nbt.4163
• The Brenner Group organized the CAGI 5 Conference on 5-7 July 2018 in Chicago.
• The Brenner group gave presentations and presented posters at ISMB 2018:
  • 7 July: Aashish Adhikari presented a poster, "Exploring the potential of exome sequencing in newborn screening" (A-391) for the General Computational Biology COSI track.
  • 8 July: Steven Brenner gave a presentation,"Revealing the hidden transcriptome: Analysis of nonsense-mediated mRNA decay target reveals mechanistic insights", for the Computational RNA Biology COSI
  • 8 July: Steven Brenner gave a keynote presentation, "Interpreting newborn genomes", for the Translational Medicine Informatics Session
  • 8 July: Gaia Andreoletti presented a poster on CAGI (A-418) for the VarI COSI track.
  • 9 July: Steven Brenner presented a poster on Genome Privacy (B-915) for the HitSeq COSI track.
  • 9 July: John-Marc Chandonia will be giving a track presentation for the 3DSIG: Structural Bioinformatics and Computational Biophysics COSI
  • In addition, the Brenner Group organized a special session at ISMB 2018 for 9 July 2018 "Advancing computational biology through critical assessments, community experiments, and crowdsourcing"
• Brenner Lab alumna Angela Brooks is named a 2018 Pew Scholar.
• Steven Brenner is the Berkeley PI for a $5M computational biology program with Tel Aviv University, funded by the Koret Foundation
• Paper published: Biesecker LG, Harrison SM on behalf of ClinGen Sequence Variant Working Group. 2018. Discontinuation of the ACMG/AMP reputable source criteria for the interpretation of sequence variants. Genetics in Medicine 20:1687-1688. PMID:29543229. doi:10.1038/gim.2018.42
• Lab member Andrew Sharo awarded a 2018 National Science Foundation (NSF) Graduate Research Fellowship (GRFP) Fellowship.
• Paper published: Tavtigian SV, Greenblatt MS, Harrison SM, Nussbaum RL, Prabhu SA, Boucher KM, Biesecker LG, on behalf of the ClinGen Sequence Variant Interpretation Task Team (ClinGen SVI). Modeling the ACMG/AMP variant classification guidelines as a Bayesian classification framework. Genetics in Medicine 20:1054-1060. doi:10.1038/gim.2017.210
• Paper published: Oetting, WS, Beroud CC, Brenner SE, Brookes AJ, Greenblatt MS, Karchin R, Mooney SD. 2018. Methods and tools for assessing the impact of genome variations: the 2017 annual scientific meeting of the Human Genome Variation Society. Human Mutation 39:454-458. PMID:29282786. PMCID:5805595. doi:10.1002/humu.23393
• Paper published: Lu JG, Bishop J, Cheyette S, Zhulin IB, Guo S, Sobreira N, Brenner SE. 2018. A novel PRRT2 pathogenic variant in a family with Paroxysmal Kinesigenic Dyskinesia and Benign Familial Infantile Seizures. Cold Spring Harbor Molecular Case Studies 4:a002287. PMID:29167286. doi:10.1101/mcs.a002287
• Paper published: Crawford DC, Morgan AA, Denny JC, Aronow BJ, and Brenner SE. 2018. Precision medicine: from diplotypes to disparities towards improved health and therapies. Pacific Symposium on Biocomputing 2018:389-399. PMID:29218899. doi:10.1142/9789813235533_0036
• The Global Alliance awards funding to Brenner Lab for its collaborative project, "Automating Approaches for Clinical Genome Interpretation."
• The 2019 Critical Assessment of Genome Interpretation (CAGI) second Special Issue of Human Mutation preprints are now largely online, including the following publications with Brenner group authors:
  • Andreoletti G, Pal LR, Moult J, Brenner SE. 2019. Reports from the fifth edition of CAGI: The Critical Assessment of Genome Interpretation. Human Mutation. in press. doi:10.1002/humu.23876
  • Clark WT, Andreoletti G, Kasak L, Bakolitsa C, Hu Z, Babbi G, Bromberg Y, Casadio R, Dunbrack R, Folkman L, Ford CT, Jones DT, Katsonis P, Kundu K, Lichtarge O, Martelli PL, Mooney SD, Nodzak C, Pal LR, Radivojac P, Savojardo C, Shi X, Zhou Y, Uppal A, Xu Q, Yin Y, Pejaver V, Wang M, Wei L, Moult J, Yu GK, Brenner SE, LeBowitz JH. 2019. Assessment of predicted enzymatic activity of alpha-N-acetylglucosaminidase (NAGLU) variants of unknown significance for CAGI 2016. Human Mutation. in press.
  • Kasak L, Hunter JM, Udani R, Bakolitsa C, Hu Z, Adhikari AN, Babbi G, Casadio R, Gough J, Guerrero RF, Jiang Y, Joseph T, Katsonis P, Kotte S, Kundu K, Lichtarge O, Martelli PL, Mooney SD, Moult J, Pal LR, Poitras J, Radivojac P, Rao A, Sivadasan N, Sunderam U, Saipradeep V, Yin Y, Zaucha J, Brenner SE, Meyn MS. 2019. CAGI SickKids challenges: Assessment of phenotype and variant predictions derived from clinical and genomic data of children with undiagnosed diseases. Human Mutation. in press. doi:10.1002/humu.23874
  • Savojardo C, Petrosino M, Babbi G, Bovo S, Corbi-Verge C, Casadio R, Fariselli P, Folkman L, Garg A, Karimi M, Katsonis P, Kim PM, Lichtarge O, Martelli PL, Pasquo A, Pal D, Shen Y, Strokach AV, Turina P, Zhou Y, Andreoletti G, Brenner SE, Chiaraluce R, Consalvi V, Capriotti E. 2019. Evaluating the predictions of the protein stability change upon single amino acid substitutions for the FXN CAGI5 challenge. Human Mutation. in press. doi:10.1002/humu.23843
  • Carraro M, Monzon AM, Chiricosta L, Reggiani F, Aspromonte MC, Bellini M, Pagel K, Jiang Y, Radivojac P, Kundu K, Pal LR, Yin Y, Limongelli I, Andreoletti G, Moult J, Wilson SJ, Katsonis P, Lichtarge O, Chen J, Wang Y, Hu Z, Brenner SE, Ferrari C, Murgia A, Tosatto SCE, Leonardi E. 2019. Assessment of patient clinical descriptions and pathogenic variants from gene panel sequences in the CAGI-5 intellectual disability challenge. Human Mutation. in press. doi:10.1002/humu.23823
  • McInnes G, Daneshjou R, Katsonis P, Lichtarge O, Srinivasan RG, Rana S, Radivojac P, Mooney SD, Pagel KA, Stamboulian M, Jiang Y, Capriotti E, Wang Y, Bromberg Y, Bovo S, Savojardo C, Martelli PL, Casadio R, Pal LR, Moult J, Brenner SE, Altman R. 2019. Predicting venous thromboembolism risk from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges. Human Mutation. in press. doi:10.1002/humu.23825
  • Voskanian A, Katsonis P, Lichtarge O, Pejaver V, Radivojac P, Mooney SD, Capriotti E, Bromberg Y, Wang Y, Miller M, Martelli PL, Savojardo C, Babbi G, Casadio R, Cao Y, Sun Y, Shen Y, Garg A, Pal D, Yu Y, Huff CD, Tavtigian SV, Young E, Neuhausen SL, Ziv E, Pal LR, Andreoletti G, Brenner SE, Kann MG. 2019. Assessing the performance of in-silico methods for predicting the pathogenicity of variants in the gene CHEK2, among Hispanic females with breast cancer. Human Mutation. in press. doi:10.1002/humu.23849
  • Monzon AM, Carraro M, Chiricosta L, Reggiani F, Han J, Ozturk K, Wang Y, Miller M, Bromberg Y, Capriotti E, Savojardo C, Babbi G, Martelli PL, Casadio R, Katsonis P, Lichtarge O, Carter H, Kousi M, Katsanis N, Andreoletti G, Moult J, Brenner SE, Ferrari C, Leonardi E, Tosatto SCE. 2019. Performance of computational methods for the evaluation of Pericentriolar Material 1 missense variants in CAGI-5. Human Mutation. in press. doi:10.1002/humu.23856
  • Kasak L, Bakolitsa C, Hu Z, Yu C, Rine J, Dimster-Denk DF, Pandey G, De Baets G, Bromberg Y, Cao C, Capriotti E, Casadio R, Van Durme J, Giollo M, Karchin R, Katsonis P, Leonardi E, Lichtarge O, Martelli PL, Masica D, Mooney SD, Olatubosun A, Pal LR, Radivojac P, Rousseau F, Savojardo C, Schymkowitz J, Thusberg J, Tosatto SCE, Vihinen M, Väliaho J, Repo S, Moult J, Brenner SE, Friedberg I. 2019. Assessing computational predictions of the phenotypic effect of Cystathionine-beta-Synthase variants. Human Mutation. in press. doi:10.1002/humu.23868
  • Hu Z, Yu C, Furutsuki M, Andreoletti G, Ly M, Hoskins RA, Adhikari AN, Brenner SE. 2019. VIPdb, a genetic Variant Impact Predictor Database. Human Mutation. in press. doi:10.1002/humu.23858
  • Chen J. 2019. A fully-automated event-based variant prioritizing solution to the CAGI5 Intellectual Disability Gene Panel challenge. Human Mutation. in press. doi:10.1002/humu.23781
  • Wang R, Wang Y, Hu Z. 2019. Using secondary structure to predict the effects of genetic variants on alternative splicing. Human Mutation. in press. doi:10.1002/humu.23790
  • Shigaki, D, Adato O, Adhikari AN, Dong S, Hawkins-Hooker A, Inoue F, Juven-Gershon T, Kenlay H, Martin B, Patra A, Penzar DD, Schubach M, Xiong C, Yan Z, Boyle AP, Kreimer A, Kulakovskiy IV, Reid JE, Unger R, Yosef N, Shendure J, Ahituv N, Kircher M, Beer MA. 2019. Integration of multiple epigenomic marks improves prediction of variant impact in saturation mutagenesis reporter assay. Human Mutation. in press. doi:10.1002/humu.23797
  • Adhikari AN. 2019. Gene-specific features enhance interpretation of mutational impact on acid alpha-glucosidase enzyme activity. Human Mutation. in press. doi:10.1002/humu.23846
  • Mount SM, Avsec Ž, Carmel L, Casadio R, Çelik MH, Chen K, Cheng J, Cohen NE, Fairbrother WG, Fenesh T, Gagneur J, Gotea V, Holzer T, Lin CF, Martelli PL, Naito T, Nguyen TYD, Savojardo C, Unger R, Wang R, Yang Y, Zhao H. 2019. Assessing predictions of the impact of variants on splicing in CAGI5. Human Mutation. in press. doi:10.1002/humu.23869
• Constantina Bakolitsa and Laura Kasak join the lab
• The Critical Assessment of Genome Interpretation (CAGI) Special Issue of Human Mutation was published, including the following publications with Brenner group authors:
  • Hoskins RA, Repo S, Barsky D, Andreoletti G, Moult J, Brenner SE. 2017. Reports from CAGI: The Critical Assessment of Genome Interpretation. Human Mutation 38:1039-1041. PMID:28544272 doi:10.1002/humu.23290
  • Daneshjou R et al. 2017. Working towards precision medicine: predicting phenotypes from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges. Human Mutation 38:1182-1192. PMID:28634997. doi:10.1002/humu.23280
  • Carraro M et al. 2017. Performance of in silico tools for the evaluation of p16INK4a (CDKN2A) variants in CAGI. Human Mutation 38:1042-1050. PMID:28440912. PMCID:5561474. doi:10.1002/humu.23235
  • Cai B et al. 2017. Matching phenotypes to whole genomes: lessons learned from four iterations of the personal genome project community challenges. Human Mutation 38:1266-1276. PMID:28544481. doi:10.1002/humu.23265
• Paulameena Shultes and Yiran Jia (URAP Students) join the Brenner Lab.
• Brenner Lab alumna Angela Brooks, featured in The Scientist
• Zhiqiang Hu (postdoctoral researcher) and Andrew Sharo (graduate student) join the Brenner lab
• Paper published: Chhibber A, French CE, Gamazon ER, Yee SW, Qin X, Theusch E, Webb A, Weiss S, Medina MW, Krauss RM, Scherer SE, Cox NJ, Giacomini KM, Brenner SE. 2017. Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. The Pharmacogenomics Journal 17:137-145. PMID:26856248. PMCID:4980276. doi:10.1038/tpj.2015.93
• Paper published: Volpi S et al. 2017. EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay. Journal of Experimental Medicine 214:623-637. PMID:28148688. doi:10.1084/jem.20161525
• Paper published: Berg JS et al. 2017. Newborn Sequencing In Genomic medicine and public Health. Pediatrics 139. PMID:28096516. PMCID:PMC5260149. doi:10.1542/peds.2016-2252
• Paper published: Srouji JR, Xu A, Park A, Kirsch JK, Brenner SE. 2017. The evolution of function within the nudix homology clan. Proteins: Structure, Function, and Bioinformatics 85:775-811. PMID:27936487. PMCID:5389931. doi:10.1002/prot.25223
• Paper published: Chandonia JM, Fox NK, Brenner SE. 2017. SCOPe: Manual curation and artifact removal in the structural classification of proteins-extended database. Journal of Molecular Biology 429:348-55. PMID: 27914894. PMCID:5272801. doi:10.1016/j.jmb.2016.11.023
• A newly discovered bacterial phylum has been named after Steven Brenner in Anantharaman et al. 2016. Nature Communications 7:13219; press release. NCBI genome sequences
• Paper published: Punwani D et al. 2016. Multisystem anomalies in severe combined immunodeficiency with mutant BCL11B. New England Journal of Medicine 375:2165-2176. PMID:27959755. PMCID:5215776. doi:10.1056/NEJMoa1509164. It is featured in a New England Journal of Medicine perspective piece, the UC Berkeley news, and the UC San Francisco news
• Steven Brenner is elected as a International Society of Computational Biology (ISCB) 2016 Fellow.
• Virginia Tartaglio (rotation student), Daniel Blank (URAP student), Mabel Furutsuki (URAP student), and Kristle Garcia (URAP student) join the Brenner lab
• Paper published: Oetting WS, Béroud C, Brenner SE, Greenblatt M, Karchin R, Mooney SD, and Sunyaev S. 2017. Non-coding variation: the 2016 annual scientific meeting of the Human Genome Variation Society. Human Mutation 38:460-463. PMID:28054414. doi:10.1002/humu.23169
• Paper published: Morgan AA, Crawford DC, Denny JC, Mooney SD, Aronow BJ, and Brenner SE. 2017. Precision medicine: data and discover for improved health and therapy. Pacific Symposium on Biocomputing 22:348-355. PMID:27896988. doi:10.1142/9789813207813_0033
• The Brenner group gave 2 talks at the 2016 ASHG Conference and the GA4GH Plenary; including Aashish Adhikari's 2016 ASHG Closing Plenary Symposium talk which was featured in a Science article
• Paper published: Karačić Z, Vukelić B, Ho GH, Jozić I, Sučec I, Salopek-Sondi B, Kozlović M, Brenner SE, Ludwig-Müller J, Abramić M. 2017. A novel plant enzyme with dual activity: an atypical Nudix hydrolase and a dipeptidyl peptidase III. Biological Chemistry 398:101-12 . PMID:27467751. doi:10.1515/hsz-2016-0141
• Postdoctoral researcher, Jingqi Chen, joins the Brenner lab
• Paper published: Nguyen V, Park A, Xu A, Srouji J, Brenner SE, Kirsch JF. 2016. Substrate specificity characterization for eight putative Nudix hydrolases. Evaluation of criteria for substrate identification within the Nudix family. Proteins: Structure, Function, and Bioinformatics 84:1810-1822. PMID:27618147. PMCID:5158307. doi:10.1002/prot.25163
• Gaia Andreoletti joins the Brenner lab as the CAGI Coordinating Postdoctoral Researcher
• Paper published: Jiang Y et al. 2016. An expanded evaluation of protein function prediction methods shows an improvement in accuracy. Genome Biology 17:184. PMID:27604469. PMCID:5015320. doi:10.1186/s13059-016-1037-6
• Paper published: Shatsky M, Dong M, Liu H, Yang LL, Choi M, Singer ME, Geller JT, Fisher SJ, Hall SC, Hazen TC, Brenner SE, Butland G, Jin J, Witkowska HE, Chandonia JM, Biggin MD. 2016. Quantitative tagless copurification: a method to validate and identify protein-protein interactions. Molecular and Cellular Proteomics 15:2186-202. PMID:27099342. PMCID:5083090. doi:10.1074/mcp.M115.057117
• Paper published: Shatsky M, Allen S, Gold BL, Liu NL, Juba TR, Reveco SA, Elias DA, Prathapam R, He J, Yang WSzakal ED, Liu H, Singer ME, Geller JT, Lam BR, Saini A, Trotter VV, Hall SC, Fisher SJ, Brenner SE, Chhabra SR, Hazen TC, Wall JD, Witkowska HE, Biggin MD, Chandonia JM, Butland G. 2016. Bacterial interactomes: interacting protein partners share similar function and are validated in independent assays more frequently than previously reported. Molecular and Cellular Proteomics 15:1539-55. PMID:26873250. PMCID:4858938. doi:10.1074/mcp.M115.054692
• Paper published online: Chhibber A, French CE, Gamazon ER, Yee SW, Qin X, Theusch E, Webb A, Weiss S, Medina MW, Krauss RM, Scherer SE, Cox NJ, Giacomini KM, Brenner SE. 2016. Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. The Pharmacogenes Journal. PMID:26856248. PMCID:4980276. doi:10.1038/tpj.2015.93
• Rotation students, Jared Bennett, Sandra Hui and Andrew Sharo join the Brenner lab
• URAP student, Jerry Li, joins the Brenner lab
• The Brenner group gave four presentations at ISMB satellites IRB-SIG, TransMed-SIG, and VarI-SIG
• Robert Wang, UC Berkeley undergrad joins the lab as a volunteer
• Andrew Neumann (systems administrator), Yaqiong Wang (postdoctoral researcher), and Xingjie Pan (bioengineering rotation student) join the Brenner lab
• Paper published: Oetting WS, Brenner SE, Brookes AJ, Greenblatt MS, Hart RK, Karchin R, Sunyaev SR, Taschner PE. Pathogenicity Interpretation in the Age of Precision Medicine: The 2015 Annual Scientific Meeting of the Human Genome Variation Society. Human Mutation. PMID:26791113. PMCID:4783187. doi:10.1002/humu.22958.
• 3 Pacific Symposium on Biocomputing papers published for Precision medicine, doi:10.1142/9789814749411_0023; Regulatory RNA, doi:10.1142/9789814749411_0039, and Genome data use in newborns, doi:10.1142/9789814749411_0052
• Paper published: Chan AY, Punwani D, Kadlecek TA, Cowan M, Brenner SE, Olson JL, Mathes EF, Sunderam U, Srinivasan R, Kuriyan J, Fu SM, Weiss A, Puck JM. Novel Autoimmune Syndrome Due to the Combined Actions of a Hypomorphic and an Activating Mutation of Zeta-Chain Associated Protein Kinase ZAP-70. Journal of Experimental Medicine. PMID:26783323. PMCID:4749924. doi:10.1084/jem.20150888
• Alumna Maki Inada's precision medicine treatment discussed by Francis Collins, Director of the NIH, in Congressional Testimony (Minute 30).
• Steven Brenner's graduate advisor Cyrus H. Chothia FRS named 2015 Dan David Laureate.
• SIFTER honored as best-performing sequence-based method in the second Critical Assessment of Function Annotation (CAFA2).
• Paper published: Caswell JL, Camarda R, Zhou AY, Huntsman S, Hu D, Brenner SE, Goga A, Ziv E. 2015. Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors. Human Molecular Genetics 24:7421-31. PMID:26472073. PMCID:4664170. doi:10.1093/hmg/ddv432
• The Brenner group gave four presentations at the 2015 ASHG and HGVS meetings
• Paper published: Brooks AN et al. 2015. Regulation of alternative splicing in Drosophila by 56 RNA binding proteins. Genome Research. PMID:26294686. PMCID:4617972. doi:10.1101/gr.192518.115
• Paper published: Fox NK, Brenner SE, Chandonia JM. 2015. The value of protein structure classification information—surveying the scientific literature. Proteins: Structure, Function, and Bioinformatics 83:2025-38. PMID:26313554. PMCID:4609302. doi:10.1002/prot.24915
• The Brenner group gave 12 presentations at the 2015 ISMB meeting and satellites IRB-SIG, AFP-SIG, VarI-SIG
• Steven Brenner's advisor, Cyrus H. Chothia FRS, will receive the ISMB Senior Scientist Award. His keynote talk will be partially presented by Steven Brenner
• PLOS Computational Biology celebrates 10th anniversary with editorial commentary from founding editors: Bourne PE, Brenner SE, Eisen MB. 2015. Ten years of PLoS^‡ Computational Biology: a decade of appreciation and innovation. PLOS Computational Biology 11:e1004317. PMCID:4479580. doi:10.1371/journal.pcbi.1004317.
• Alumna Angela Brooks starts faculty position at University of California Santa Cruz Genomics Institute.
• Paper published: Sahraeian SME, Luo KR, Brenner SE. 2015. SIFTER search: a web server for accurate phylogeny-based protein function prediction. Nucleic Acids Research 43:W141-W147. PMID:25979264. PMCID:4489292. doi:10.1093/nar/gkv461
• Alumnus Ed Green makes donation to the Brenner Laboratory.
• Paper published: Patel JP, et al. 2015. Nijmegen breakage syndrome detected by newborn screening for T cell receptor excision circles (TRECs). Journal of Clinical Immunology 35:227-233. PMCID:4352190. doi:10.1007/s10875-015-0136-6.
• Two URAP students join the Brenner lab: Roshni Patel and Tong Zhang
• Three rotation students join the Brenner lab: Patrick West (Plant Biology), Carlos Buen Abad Najar (Computational Biology), and Katrina Kalantar (Bioengineering)
• Aditya Rao joins the Brenner lab as a visiting researcher.
• Paper published: Punwani D, et al. 2015. Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation. Journal of Clinical Immunology 35:135-146. PMCID:4352191 doi:10.1007/s10875-014-0125-1
• Paper published: Lareau LF, Brenner SE. 2015. Regulation of splicing factors by alternative splicing and NMD is conserved between kingdoms yet evolutionarily flexible. Molecular Biology and Evolution 32:1072-1079. PMCID:4379411. doi:10.1093/molbev/msv002
• Paper published: Gerstein M, et al. 2014. Comparative analysis of the transcriptome across distant species. Nature 512:445-448. doi:10.1038/nature13424
• Paper published: Boyle A, et al. 2014. Comparative analysis of regulatory information and circuits across distant species. Nature 512:453-456. doi:10.1038/nature13668
• Collaborator Jennifer Puck featured in San Francisco Chronicle article: 'Bubble boy' disorder more common than thought, related to JAMA paper on newborn screening for SCID, doi:10.1001/jama.2014.9132
• Brenner group gives 5 presentations at 2014 ASHG
• Courtney French receives Poster Award at 2014 Computational Biology Departmental Retreat
• Anna Desai awarded a Kirschtein NRSA F31 graduate fellowship for 2014-2017
• Kunal Kundu receives Best Poster prize at ISMB 2014
• Mohammad Sahraeian receives Best Poster prize at AFP/CAFA 2014
• Brenner group gives 22 presentations at 2014 ISMB and satellite meetings
• Steven Brenner's postdoctoral advisor Michael Levitt awarded 2013 Nobel Prize in Chemistry
• John-Marc Chandonia's postdoctoral advisor Martin Karplus awarded 2013 Nobel Prize in Chemistry