Emma Hill's Homepage

About Me

Where I am at and where I have been:

I am currently a post-doc in Steven Brenner's group at U.C. Berkeley.

I carried out my Ph.D. in Cyrus Chothia's group at the MRC-LMB and the University of Cambridge where I was a member of Queens' College in the U.K.

I obtained my undergraduate degree (B(Sc) hons in Genetics) at The University of Manchester.
Click here for a reasonably recent CV.

Other Stuff About Me

Current Research:

Structure, sequence, function and phylogenetic analyses of the Nudix proteins: details.

Investigation of the Intra-family relationships within SCOP: details.

In general I am interested in relationships between sequence and structure - in particular between homolgous proteins that have low sequence identity. These proteins raise the question as to why and how their structure has been conserved despite high sequence divergence?

We now have a wealth of sequence and structure data thanks to genome sequencing and structral genomics initiatives. My work aims at starting to bring together data from these resources and analyse protein families to levels that were not feasible before the availability of such quantities of data.


Structural studies of the nudix hydrolase DR1025 from Deinococcus radiodurans and ligand complexes.
Ranatunga W*, Hill EE*, Mooster JL, Holbrook EL, Schulze-Gahmen U, Xu WL, Bessman MJ, Brenner SE, Holbrook SR. JMB (2004) 339, (1), 103-116. [PDF].
(* these authors contributed equally)

Sequence conservation in families whose members have little or no sequence similarity: the four-helical cytokines and cytochromes.
Emma E. Hill, Veronica Morea & Cyrus Chothia. JMB (2002) 322, (1), 205-233. [PDF].
This paper has a must-read recommendation on the Faculty of 1000 website.

The cadherin superfamily of proteins in Caenorhabditis elegans and Drosophila melanogaster.
Emma Hill, Ian Broadbent, Cyrus Chothia & Jonathan Pettitt. JMB (2001) 305, (5), 1011-1024. [PDF].
See also: Cadherin Superfamily Genes.

Book Chapter

Evolution of the protein repertoire.
Christine Vogel, Rajkumar Sasidharan & Emma E. Hill.
To be published in Encyclopedia of Molecular Cell Biology and Molecular Medicine (EMCBMM) Second Edition (2004-5)
Ed in chief: Robert A. Meyers, Wiley-VCH publishers

Ph.D. Thesis

Ph.D. Thesis for the Cambridge University degree of Doctor of Philosophy: Evolution of Protein Families: Genome Sequences and Three Dimensional Structures.
Emma E. Hill (2001)