SCOP Intra-Family Relationships
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The Structural Classification of Proteins: SCOP is to some a magical
hierarchical classification of protein structures. As is simplified greatly in the figure on the right - SCOP
classifies protein structures at many levels from overall class (all alpha helix, all beta strand etc.) down to
protein domain and species level.
The SCOP tree takes the protein domain as the evolutionary unit and represents evolutionary relationships between proteins such that anything classified within a superfamily is evolutionarily related. Wheras protein domains within the same class or fold are not necessarily evolutionarily related. We are investigating how families in the same superfamily are related to one another and why or how they have evolved into distinct families. In particular we are looking at Superfamilies that have greater than 2 families. |
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